منابع مشابه
Absence of NOTCH1 gene mutations in MALT lymphomas.
The NOTCH family of genes encodes a set of four transmembrane receptors that function in cell fate decisions during the development of many cell types, including B-cells, and recent studies have indicated an important oncogenic role for NOTCH activation in various B-cell malignancies (Mirandola et al, 2011). In particular, NOTCH signalling is known to be important for the generation of marginal...
متن کاملNon-MALT marginal zone lymphomas.
The concept of marginal zone B-cell lymphomas was developed in the 1990s for lymphomas whose cells originate from B lymphocytes normally present in a distinct anatomical location, the so-called ‘marginal zone’ (MZ). MZ has been described in the lymphoid organs—spleen and lymph nodes—and in nonlymphoid organs—mucosa-associated lymphoid tissue (MALT) or non-mucosal tissue such as skin, orbit and ...
متن کاملImmunogenicity of recurrent mutations in MYD88 and EZH2 in non-Hodgkin lymphomas
A fundamental challenge in cancer genomics is to design effective, personalized treatments based on the mutational profiles of tumors. Pharmacological targeting of the numerous aberrant pathways found in individual tumors remains exceedingly challenging, but T cellbased therapies are an attractive alternative because of the enormous diversity and exquisite specificity of antigen recognition. We...
متن کاملThe management of nongastric MALT lymphomas.
The group of marginal zone B-cell lymphomas (MZL) comprises three different entities, extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (currently called MALT lymphoma), nodal marginal zone B-cell lymphoma (previously known as monocytoid lymphoma), and splenic marginal zone B-cell lymphoma (with or without circulating villous lymphocytes).[1-3] Primary splenic and no...
متن کاملHuman Cancer Biology Recurrent Mutations of MYD88 and TBL1XR1 in Primary Central Nervous System Lymphomas
Purpose: Our objective was to identify the genetic changes involved in primary central nervous system lymphoma (PCNSL) oncogenesis and evaluate their clinical relevance. Experimental Design: We investigated a series of 29 newly diagnosed, HIV-negative, PCNSL patients usinghigh-resolution single-nucleotide polymorphism (SNP) arrays (n1⁄429) andwhole-exome sequencing (n1⁄4 4) approaches. Recurren...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2012
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2012.09176.x